investigation of dibromo and n-bromoacetyl derivatives of [b] carbazole-synthesis and antibacterial evaluation

investigation of dibromo and n-bromoacetyl derivatives of [b] carbazole-synthesis and antibacterial evaluation

the synthesis, structure and biological activity of carbazole compounds has been long focus of research interests in the field of medicinal chemistry. 5,8-dibromo-5,6-dihydro(3,2-a) carbazole a have prepared in good yield by a free radical bromination reaction of 8-bromo-5,6-dihydro9(3,2-a)carbazole with n-bromosuccinimide in carbontetrachloride at ambient temperature. compound 2 have prepared by free radical brimination method in carbontetrachloride at 40°c.

synthesis of compound c have carried out by free radical bromination with 5-bromo-1,2,3,4-tetrahydrocyclopenta(b)indole as reactant, in dichloromethane at ambient temperature. compound 2, 4, and 6 were synthesized by n-bromoacetylation method using bromoacetylbromide as reactant. all the synthesized compounds were characterized and confirmed by various instrumental techniques viz, uv-visible, ftir, 1h nmr, 13c nmr and mass spectroscopy. all the synthesized compounds were subjected to the antibacterial evaluation with standard ciprofloxacin. the results showed that the synthesized compounds exhibit excellent antibacterial activity.