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نویسندگان مقالات پربازدید :
بیوشیمی مولکولی و سلولی 2013
جزئیات رویداد
اینستاگرام تی پی بین
همایش ، رویداد ، ژورنال
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  • anti-tumor activity of the x-linked inhibitor of apoptosis (xiap) inhibitor embelin in gastric cancer cells

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    جزئیات بیشتر مقاله
    • تاریخ ارائه: 1392/07/24
    • تاریخ انتشار در تی پی بین: 1392/07/24
    • تعداد بازدید: 1349
    • تعداد پرسش و پاسخ ها: 0
    • شماره تماس دبیرخانه رویداد: -
     this study investigated the anticancer effects of embelin in human gastric cancer cells and the underlying molecular mechanisms. gastric cancer cells were treated with embelin and 5-fu for methyl-thiazolyl-tetrazolium bromide cell viability assay and flow cytometric detection of cell viability and apoptosis. protein pathway array (ppa) and western blot were used to investigate differentially expressed proteins in embelin-treated gastric cancer cells. embelin reduced gastric cancer cell viability, induced apoptosis, and enhanced 5-fu antitumor activity in gastric cancer cells. mechanistically, embelin induced cell cycle arrest at the s and g2/m phases. molecularly, embelin downregulated expression of x-linked inhibitor of apoptosis and cell cycle-regulatory proteins, such as cdk1, cdc25b, cdc25c, cyclinb1, and cdk2. ppa analysis showed that embelin modulated several pathways that are associated with cell growth and apoptosis, such as pi3k/akt, jak/stat, p38 mapk, and p53. the data from the current study implied that reduction of gastric cancer cell viability after treatment with embelin was through cell cycle arrest at the s and g2/m phases and apoptosis.

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