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بیوشیمی مولکولی و سلولی 2013
جزئیات رویداد
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  • increased expression of microrna-9 predicts an unfavorable prognosis in human glioma

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    • تاریخ ارائه: 1392/07/24
    • تاریخ انتشار در تی پی بین: 1392/07/24
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     microrna-9 (mir-9) has been found to be upregulated along with tumor progression of gliomas by microarray-based expression profiling, and also be strongly linked to glioblastoma subtypes. however, its prognostic value in glioma is still elusive. mir-9 expression in human gliomas and nonneoplastic brain tissues was measured by real-time quantitative rt-pcr assay. mir-9 expression in glioma tissues was significantly higher than that in corresponding nonneoplastic brain tissues (p < 0.001). the increased expression of mir-9 was more frequently observed in glioma tissues with high who grade than those with low who grade tissues (p = 0.001). the expression levels of mir-9 in glioma tissues with low karnofsky performance score (kps) were also significantly higher than those with high kps (p = 0.008). moreover, the overall survival of glioma patients with high mir-9 expression was obviously lower than that with low mir-9 expression (p < 0.001). multivariate analysis further showed that high mir-9 expression was an independent prognostic factor for overall survival in glioma patients (p = 0.01). more importantly, the subgroup analyses indicated that the overall survival of glioma patients with high who grade (iii–iv) was significantly worse for high mir-9 expression group than for low mir-9 expression group (p < 0.001), but no significant difference was found for patients with low who grade (i–ii). these findings suggest for the first time that the increased expression of mir-9 may play an important role in tumor progression in human gliomas. mir-9 might be a useful marker for predicting the clinical outcome of glioma patients, especially for advanced subtypes.

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