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نویسندگان مقالات پربازدید :
تکنولوژی پودر پیشرفته
جزئیات رویداد
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همایش ، رویداد ، ژورنال

  • optimization and characterization of direct coating for ibuprofen particles using a composite fluidized bed

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    جزئیات بیشتر مقاله
    • تاریخ ارائه: 1393/01/01
    • تاریخ انتشار در تی پی بین: 1393/01/01
    • تعداد بازدید: 507
    • تعداد پرسش و پاسخ ها: 0
    • شماره تماس دبیرخانه رویداد: -
     ibuprofen particles (mean particle size, 27 μm and melting point, 76 °c) as core materials were directly coated with a water-soluble polymer. the primary particles were preserved using a composite fluidized bed with a dispersing mechanism at the bottom of the fluidized bed apparatus. coated primary particles were obtained under the following 3 conditions: (1) setting the spray air flow rate at 10 l/min from the initial to 2% coating, (2) adding the low-viscosity water-soluble polymer macrogol 6000 to the hypromellose coating solution, and (3) changing the spray air flow rate to 15 l/min from 2% coating. the particles obtained were confirmed to be coated primary particles by scanning electron microscopy of their cross sections prepared by the cryo-focused ion beam method. the dissolution test showed a marked improvement in the solubility of ibuprofen from the coated primary particles compared with that of a physical mixture. in conclusion, the optimization of the direct coating process made it possible to undertake primary particle coating of a raw material that has a low melting point and a particle size of not more than 50 μm. primary particle coating contributes to improvements in the physicochemical properties of drugs.

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