bacterial enzymes – hyaluronidase

bacterial enzyme ‘hyaluronidase’ is a complex polysaccharide degrading enzyme that cleaves â-glcnaclinkage of hyaluronate (ha) by âelimination process. it is synthesized by a spectrum of grampositive bacteria which serve as potential contributors to a multitude of infectious diseases in human beings. especially, group a streptococcus bacteria (gas) have evolved several orders of magnitude to attack the host organism and establish infection. hyaluronidase led pathogenic/ infectious cycle is accomplished through a cascade of events where an escape from the host.s immunity is very important. in this regard, a variety of factors are utilized by hyaluronidases which determine the successful bacterial penetration into hosts, like the use of substrate ha and/or it.s enveloping capsule as energy source during ha lysis, genetic variation among the bacterial strains in the form of allelic polymorphisms, hyaluronidase enzyme structure-driven substrate binding properties etc. previous studies have furnished better insights on nucleotide sequences of hyaluronidase genes and immunopathogenesis. however, for a better understanding of hyaluronidase association with bacteria and overall host-pathogen interaction, much investigation and literature support is still needed.