effect of domperidone on lactation in low milk supply women in tehran, iran: a randomized clinical trial effect of domperidone on women lactation

effect of domperidone on lactation in low milk supply women in tehran, iran: a randomized clinical trial effect of domperidone on women lactation

introduction: the promotion of breastfeeding is a simple and efficient strategy in reducing morbidity and mortality among newborns worldwide. domperidone is a blocker of dopamine receptors, which causes prolactin release. we aimed to determine the efficacy of domperidone on the amount of breast milk secretion among mothers with low-milk-production. materials and methods: this interventional study was performed on 16 consecutive low-milk-producing women who attending to azad university hospitals in tehran, iran during 2013-2014.

eligible mothers received domperidone at a dose of 30 mg orally per day (10 mg tablet three times daily) for a week. breast-milk volume, as well as the serum levels of prolactin, were determined before and after the intervention. also, any adverse drug reactions were recorded. results: the mean breast milk volume was 173.75 ± 47.73 and 326.88 ± 26.19 ml before and after the intervention, respectively. also, administered of domperidone cloud significantly increase of %53.1 (p < 0.001) in daily milk production. also, the mean serum prolactin level was 161.19 ± 19.13 and 254.0 ± 25.53 ng/ml, before and after medications, respectively, which showed a significant increase of %63.46 (p = 0.0001). conclusion: domperidone increases the volume of breast milk production among nursing mothers. there was no drug-related side effect for mothers and infants.