محبوبترین نویسندگان :
نویسندگان مقالات پربازدید :
آکتا بیومتریال
جزئیات رویداد
همایش ، رویداد ، ژورنال
اینستاگرام تی پی بین
حوزه های تحت پوشش رویداد

  • immediate production of a tubular dense collagen construct with bioinspired mechanical properties

    نویسندگان :
    کلمات کلیدی :
    جزئیات بیشتر مقاله
    • تاریخ ارائه: 1392/01/01
    • تاریخ انتشار در تی پی بین: 1392/01/01
    • تعداد بازدید: 553
    • تعداد پرسش و پاسخ ها: 0
    • شماره تماس دبیرخانه رویداد: -
     the intrinsic complexity of tissues and organs demands tissue engineering approaches that extend beyond planar constructs currently in clinical use. however, the engineering of cylindrical or tubular tissue constructs with a hollow lumen presents significant challenges arising from geometrical and architectural considerations required to tailor biomaterials for tissue and organ repair. type i collagen is an ideal scaffolding material due to its outstanding biocompatibility and high processability. however, the highly hydrated nature of collagen hydrogels results in their lack of mechanical properties and instability, as well as extensive cell-mediated contraction, which must be overcome to achieve process control. herein, tubular dense collagen constructs (tdccs) were produced simply and rapidly (in less than 1 h) by circumferentially wrapping plastically compressed dense collagen gel sheets around a cylindrical support. the effects of collagen source, i.e. rat-tail tendon and bovine dermis-derived acid solubilized collagen, and concentration on tdcc properties were investigated through morphological, mechanical and chemical characterizations. both tensile strength and apparent modulus correlated strongly with physiologically relevant collagen gel fibrillar densities. the clinical potential of tdcc as a tubular tissue substitute was demonstrated mechanically, through circumferential tensile properties, theoretical burst pressure, which ranged from 1225 to 1574 mm hg, compliance values of between 8.3% to 14.2% per 100 mm hg and suture retention strength in the range of 116–151 grams-force, which were compatible with surgical procedures. moreover, nih/3t3 fibroblast viability and uniform distribution within the construct wall were confirmed up to day 7 in culture. tdccs with fibrillar densities equivalent to native tissues can be readily engineered in various dimensions with tunable morphological and mechanical properties, which can be easily handled for use as tissue models and adapted to clinical needs.

سوال خود را در مورد این مقاله مطرح نمایید :

با انتخاب دکمه ثبت پرسش، موافقت خود را با قوانین انتشار محتوا در وبسایت تی پی بین اعلام می کنم
مقالات جدیدترین رویدادها
مقالات جدیدترین ژورنال ها