• association of tnf-α and ptpn22 snps with the risk and clinical outcome of type 1 diabetes

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    • تاریخ ارائه: 1392/07/24
    • تاریخ انتشار در تی پی بین: 1392/07/24
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     type 1 diabetes mellitus (t1dm) begins with aberrant inflammatory process followed by auto-destruction in genetically susceptible individuals. therefore, we hypothesized that gain-of-function allelic variants tnf-α-238a, -308a and ptpn22 1858t could be associated not only with t1dm development but also with the clinical outcome in patients of bosnia and herzegovina. a total of 402 subjects were enrolled in the association study. snps were determined by pcr-rflp. data was analyzed by graphpad prism and sigma stat 3.5 software. genotypes frequencies at tnf-α-238 and -308 loci were not statistically different between patients and controls. in contrast, distribution of genotypes at the 1858 position of ptpn22 was significantly different, due to higher frequency of gain-of-function gene variants in patients than controls. moreover, long term glucose regulation (based on hba1c level) was significantly worse in patients with the risk tnf-α-308a allele than in patients with non-risk (g) allele. however, patients with the risk allele of both genes (tnf-α-308a and ptpn22 1858t) had the worst glycemic control, suggesting that those two work synergistically. in conclusion, in a cohort from bosnia and herzegovina tnf-α-308a allele is significantly associated with the worse long-term glucose control, but ptpn22 1858t allele is significantly associated with diabetes development.

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