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مواد زیستی
جزئیات رویداد
همایش ، رویداد ، ژورنال
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  • prolongation of skin allograft survival in rats by the transplantation of microencapsulated xenogeneic neonatal porcine sertoli cells

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    • تاریخ ارائه: 1391/01/01
    • تاریخ انتشار در تی پی بین: 1391/01/01
    • تعداد بازدید: 641
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    • شماره تماس دبیرخانه رویداد: -
     skin rejection remains a major hurdle in skin reconstructive transplantation surgery. in fact, 85% of the grafted patients experience at least one episode of acute skin rejection in the first year. it has been observed that sertoli cells (sc), when co-transplanted with allo- or xenogeneic cell/tissues, can induce graft acceptance in the absence of systemic immunosuppression. a method aimed at significantly prolonging skin allografts in rats transplanted with barium alginate-based microencapsulated xenogeneic porcine sc (sc-mcs) is described. results demonstrated that intraperitoneal (ip) transplantation of sc-mcs with high cellular viability and function can significantly prolong allogeneic skin grafts when compared to transplantation controls receiving only empty alginate capsules (e-mcs). lymphocytic infiltration at the skin graft site was not observed in 80% of the sc-mcs transplanted rats and these recipient animals showed a significant increased expression of t regulatory (tregs) cells when compared to e-mcs transplantation controls. the findings of this report further substantiate the positive therapeutic effects of sc on transplantation technology mediated by sertoli cell-induced alterations of the host's immune system and indicate new perspectives and new strategies for successful skin tissue allografts.

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