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نویسندگان مقالات پربازدید :
مواد زیستی
جزئیات رویداد
همایش ، رویداد ، ژورنال
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  • simultaneous nuclear imaging and intranuclear drug delivery by nuclear-targeted multifunctional upconversion nanoprobes

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    • تاریخ ارائه: 1391/01/01
    • تاریخ انتشار در تی پی بین: 1391/01/01
    • تعداد بازدید: 923
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    • شماره تماس دبیرخانه رویداد: -
     nuclear-targeted therapy by delivering anticancer drug directly into cancer cell nuclei can elicit synergistic therapeutic effects and kill these cancer cells with much enhanced efficiencies. besides nuclear targeting, another difficulty in nuclear-targeted therapy is how to achieve real-time monitoring of the therapy process simultaneously. in this article we report on the development of multifunctional upconversion nanoparticles (ucnps) which were able to target cancer cell nuclei, and thus deliver the anticancer drug directly to the nuclear region and simultaneously image cell nucleus by magnetic resonance (mr)/upconversion fluorescent for real-time guidance of their therapeutic action simultaneously. the er/yb-doped nayf4 core and nagdf4 shell endow the core/shell structured ucnps with enhanced upconversion fluorescent imaging and more sensitive t1-mr imaging performances, and the surface conjugation of tat peptide served as a key role in the nuclear targeting and nuclear transport process. this multifunctional ucnps-based nano-theranostic was used to improve the efficacy of dox in hela humor tumor models, by direct dox delivery to the nucleus under the synchronous monitoring of the nano-theranostics. further development of this technology may provide more exciting opportunities in treating cancer disease by nuclear-targeted therapy.

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