synthesis and crystallization procedure of piperidin-4-one and its derivatives: an update

synthesis and crystallization procedure of piperidin-4-one and its derivatives: an update

piperidine is a heterocyclic chemical molecule that is forming by hydrogenating pyridine. in natural and pharmaceutically active drugs, the piperidine ring is an essential molecular component. several crystal structures of piperidine-4-ones and their derivatives are reported for their medicinal value.

while several methods of piperidin-4-one crystallization have been developed to obtain a crystal structure, novel approaches are still needed. a review of the synthesis and crystallization procedure of piperidin-4-ones and its derivatives is outlined in this review paper.