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  • a framework for efficient process development using optimal experimental designs

    جزئیات بیشتر مقاله
    • تاریخ ارائه: 1392/07/24
    • تاریخ انتشار در تی پی بین: 1392/07/24
    • تعداد بازدید: 927
    • تعداد پرسش و پاسخ ها: 0
    • شماره تماس دبیرخانه رویداد: -
     

    introduction

    the aim of this study was to develop and demonstrate a framework assuring efficient process development using fewer experiments than standard experimental designs.

    methods

    a novel optimality criterion for experimental designs (iw criterion) is defined that leads to more efficient process development because: (a) prior knowledge is used in the experimental design to focus on optimal processing conditions and (b) a lean design is used which can dramatically reduce the number of experiments compared to standard designs. in this way, the criterion serves as a framework to connect a series of screening and optimization designs.

    results

    the philosophy behind the iw criterion is explained including a detailed step-wise discussion how to apply it in practice. moreover, its advantages were shown in an industrial process development case using a screening and an optimization design that were not explicitly connected. in this paper, a reduction of 21% of experiments could be obtained compared to the traditional approach using standard experimental designs and no framework.

    conclusions

    the iw criterion is a valuable tool to increase accuracy and to speed up research that contain sets of experiments and where prior knowledge is already available or will be derived using screening designs.

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