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همایش ، رویداد ، ژورنال
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  • جزئیات بیشتر مقاله
    • تاریخ ارائه: 1392/07/24
    • تاریخ انتشار در تی پی بین: 1392/07/24
    • تعداد بازدید: 1209
    • تعداد پرسش و پاسخ ها: 0
    • شماره تماس دبیرخانه رویداد: -
     introduction

    the suitability of vapor-phase hydrogen peroxide for the decontamination of different-sized narrow cavities and complex geometrical structures were investigated in this paper.

    methods

    a cavity test block was used, and cavities made from different materials were tested with variable entrance heights and cavity depths. at the end of each cavity, biological indicators were exposed as a microbiological challenge for vapor-phase hydrogen peroxide penetration. within this study, the test block with the biological indicators was subjected to different decontamination cycles in a production isolator. inoculation level, cycle length, hydrogen peroxide, and water concentration were varied.

    results

    the ratio of cavity entrance height to depth was found to be critical for decontamination success by biological indicators exposed inside the cavities. the higher the ratio, the more spores could be inactivated. inactivation is also effected by exposure time and hydrogen peroxide concentration.

    conclusion

    the results indicate that the entrance height of the cavities should not be smaller than 6 mm and the cavity depth should not exceed 30 mm. if smaller cavities cannot be avoided, high peroxide concentration (800 ppm) and prolonged cycle times were shown to significantly enhance the penetration into dead-ended cavities under diffusive conditions.

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