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  • design expert-supported development and validation of high-performance thin-layer chromatographic stability-indicating (hptlc) method: an application in quantitative analysis of ropinirole in the bulk drug and in marketed dosage forms

    جزئیات بیشتر مقاله
    • تاریخ ارائه: 1392/07/24
    • تاریخ انتشار در تی پی بین: 1392/07/24
    • تعداد بازدید: 892
    • تعداد پرسش و پاسخ ها: 0
    • شماره تماس دبیرخانه رویداد: -
     a simple, precise and stability-indicating thin-layer chromatographic method for estimation of ropinirole hcl was developed and validated as per ich guidelines. the mobile phase consisted of acetone–cyclohexane–6 m ammonia solution (8:5.5:0.5, v/v/v). scanning the drug was done at 250 nm. compact spots for ropinirole hcl were found at an r f value of 0.51 ± 0.002. the linear regression analysis data for the calibration plots showed good linear relationship with r 2 0.9976 ± 0.0011 in the working concentration range of 100–3,000 ng spot−1. the method was validated for precision, accuracy, ruggedness, robustness, specificity, recovery, limit of detection (lod), and limit of quantitation (loq). the lod and loq were 12.89 and 42.53 ng spot−1, respectively. the drug was subjected to degradation; the peaks of degradation products were well resolved from the standard with significantly different r f values. hence, this method can be used for quality control assay of ropinirole.

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