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  • enhanced α-ketoglutaric acid production in yarrowia lipolytica wsh-z06 by an improved integrated fed-batch strategy

    جزئیات بیشتر مقاله
    • تاریخ ارائه: 1390/01/01
    • تاریخ انتشار در تی پی بین: 1390/01/01
    • تعداد بازدید: 640
    • تعداد پرسش و پاسخ ها: 0
    • شماره تماس دبیرخانه رویداد: -
     this study aimed at enhancing α-ketoglutaric acid (α-kg) production by yarrowia lipolytica wsh-z06. batch culture experiments demonstrated that caco3 and a relatively low ph (3.0) in the α-kg production phase contributed to α-kg synthesis. using a two-stage ph control strategy, in which ph was buffered by caco3 in the growth phase and then maintained at 3.0 in the α-kg production phase, the yield of α-kg reached 53.4 g l−1. in the later phase of batch fermentation, the glycerol was exhausted but synthesis of α-kg did not cease. therefore, glycerol was fed with an integrated fed-batch mode, and α-kg production increased to 66.2 g l−1 with a productivity of 0.35 g l−1 h−1. compared to optimal batch culture, α-kg production and productivity were enhanced by 23.9% and 16.7%, respectively. the two-stage ph control strategy, constant feeding approach and lower ph in later phase would be useful for α-kg industrial production.

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