a mass–length scaling law for modeling muscle strength in the lower limb

musculoskeletal computer models are often used to study muscle function in children with and without impaired mobility. calculations of muscle forces depend in part on the assumed strength of each muscle, represented by the peak isometric force parameter, which is usually based on measurements obtained from cadavers of adult donors. the aim of the present study was twofold: first, to develop a method for scaling lower-limb peak isometric muscle forces in typically-developing children; and second, to determine the effect of this scaling method on model calculations of muscle forces obtained for normal gait. muscle volumes were determined from magnetic resonance (mr) images obtained from ten children aged from 7 to 13 yr. a new mass–length scaling law was developed based on the assumption that muscle volume and body mass are linearly related, which was confirmed by the obtained volume and body mass data. two musculoskeletal models were developed for each subject: one in which peak isometric muscle forces were estimated using the mass–length scaling law; and another in which these parameters were determined directly from the mr-derived muscle volumes. musculoskeletal modeling and quantitative gait analysis were then used to calculate lower-limb muscle forces in normal walking. the patterns of muscle forces predicted by the model with scaled peak isometric force values were similar to those predicted by the mr-based model, implying that assessments of muscle function obtained from these two methods are practically equivalent. these results support the use of mass–length scaling in the development of subject-specific musculoskeletal models of children.